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| 生化科研試劑 >> 抗體產品 >> 一抗 |
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Cytokeratin 8
Rabbit Monoclonal IgG |
| 別????名： |
Cytokeratin-8, CK-8, Keratin-8, K8 |
| 貨號 |
品名 |
規格 |
包裝 |
單價 |
貨期 |
庫存 |
| 1227177694 |
Cytokeratin 8 |
|
100ul |
詢價 |
現貨 |
3天 |
| 提示信息：偏遠地區如新疆西藏寧夏甘肅等地可能無法運送液體，下單前請聯系客服。 |
| 性 狀： |
【反應特異性】Human
【克隆 ID】EP1628Y
【用途】WB , IHC , ICC , FC , IP
【抗原分子量】52 kDa |
| 質量標準： |
【產品介紹】Keratins, the intermediate filament proteins
of epithelial cells, connect to desmosomes, the
cell-cell adhesion structures at the surface membrane.
Among the various intermediate filament (IF)
proteins, cytokeratin 8 (CK8) is especially remarkable as
it is produced early in embryogenesis, is the only
type-II CK occurring in many simple epithelial cells,
a n d can also be synthesized in certain
non-epithelial cells (1). Keratin 8 a n d 18 (CK8/18)
are the maj o r keratin pair in simple-type epithelia,
as found in the liver, pancreas, a n d intestine (2).
While K8/K18 are essential f o r maintaining
structural integrity, there is accumulating
evidence indicating that they also exert
non-mechanical functions. It has been rep o r ted
that K8/K18-free hepatocytes from K8-null mice are
m o r e sensitive to Fas-mediated apoptosis, in line with
an increased Fas density at the cell surface a n d
an altered c-Flip regulation of the anti-apoptotic
ERK1/2 signaling pathway (3).
WB: 1:25,000 50,000
IHC: 1:250 500
ICC: 1:100 250
Flow Cytometry: 1:20
IP: 1:70
A. Western blot analysis on A431 cell lysate using
anti-CK8 RabMAb(cat. # 2032-1), dilution 1:50,000. B. Immunohistochemical analysis of paraffin-embedded
human breast adenocarcinoma using anti-CK8
RabMAb (cat. #2032-1). |
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